Welcome to the NanoImmuno Imaging & Single-Molecule Biotechnology Group!
Our research drives innovations at the intersection of single-molecule and superresolution microscopy, immunobiology, and nanobiotechnology, spanning both fundamental discoveries and translational applications.
Innovations in Chemical Biology & Drug Discovery
- Mapping cytokine transport and release from immune cells at the single-vesicle level
- Discovering mechanisms of action for therapeutic antibodies at the single-antibody level
- Assessing targeted protein degradation in live cells
- Evaluating drug, vaccine delivery, and nanomedicine at the nanoscale
Innovations in Bioanalytical & Biophysical Chemistry
- Assessing nanoscale membrane biophysics in immune cells
- Advancing quantitative in situ superresolution imaging techniques
- Unveiling spatiotemporal regulations of biological functions through low-affinity DNA-protein, RNA-protein, and protein-protein interactions
- Dissecting photophysical properties of engineered nanoparticles at the single-particle level
Innovations in Materials, Nanoscience, and Energy
- Single-molecule mapping of electrochemical activities
- Elucidating nano-bio interactions in the context of phototherapy using exogenous nanomaterials
Innovations in Immune Disorders and Blood Cancers
- Modulating cytokine production at the transcriptional, translational, and transport levels in immunotherapies and autoimmune conditions
- Phenotyping engineered T cells against lymphoma and leukemia
Funding
